Observing Life in Motion
Biological systems compute through fast, distributed, and adaptive dynamics that are difficult to measure with existing tools. Our research focuses on developing quantitative optical instrumentation to measure biological activity with high temporal precision, stability, and interpretability, and on using these measurements to understand how cells—and particularly neurons—process information during behavior and learning.
Research Areas
Systems-Level Inference from Single Neurons
By measuring synaptic glutamate release at spine resolution, we use single neurons as sensors of presynaptic population activity. This enables inference of network dynamics during behavior and learning.
Quantitative optical measurements of cellular physiology
We develop quantitative imaging methods that enable stable measurements of biological activity during behavior and across time.
Photophysics of dark states
Fluorescent probes are dynamical systems, and exploiting their non-equilibrium states enables new imaging modalities.
News
January 5, 2026: Patch clamp extraordinarie Jose Zepeda joins. Welcome Jose!
March 10, 2025: The Biological Dynamics & Instrumentation Group is created! Instrumentation whiz Dalia joins as the first teammate. Welcome Dalia!
Resources
- About HHMI Janelia Research Campus
- HHMI’s values
- Being a postdoc at Janelia
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